I just recently finished the E8500 review on the X38 version of the board - and I was amazed there at the 4.27GHz I obtained. The X38 was usable up to 500MHz FSB, but I found that the Asus P5E3 Premium X48 could be stabilized as high as 525MHz - albeit with a lower multiplier for the CPU, resulting in lower performance than the 9.5x460 speed I found to be the best performer. Therefore for the best performance overclock I backed down to a mere 460x9.5 setting.
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